(2) Salvage process i.e. De novo synthesis of nucleotides does not take place in brain and erythrocytes, making salvage pathway indispensable for them The salvage pathway requires no ATP and accounts for 90% of nucleotide biosynthesis. This pathway supplies ribose sugar for the formation of the nucleotide. The salvage of pyrimidine bases has less clinical significance than that of the purines, owing to the solubility of the by-products of pyrimidine catabolism. Each category has at least one description. UMP, which is used to synthesize UDP, UTP, dTTP, CTP, and dCTP, is the common metabolite between the de novo and the salvage pyrimidine synthesis pathway. I. De-novo synthesis (synthesis from scratch): it is a biochemical pathway in which nucleotides are synthesized new from simple precursor molecules. Nucleotide Synthesis (De-novo and Salvage Pathways of Purine & Pyrimidine Biosynthesis PPT by easybiologyclass) 1. sary for the synthesis of RNA, DNA, nucleotide-activated sugars, and lipids [3]. (1) de-novo synthesis and (2) synthesis by salvage pathways. Classify each description as the de novo pathway, salvage pathway, or both pathways of pyrimidine nucleotide synthesis. APRT is inhibited by AMP. The abbreviation PRPP is used for 5-phosphoribosyl-1-pyrophosphate. Its regulation occurs by competitive inhibition by IMP and GMP. The pyrimidine synthesis is a similar process than that of Purines(Purines Synthesis).In the de novo synthesis of Pyrimidines, the ring is synthesized first and then it is attached to a ribose-phosphate to for a pyrimidine nucleotide.Pyrimidine rings are assembled from bicarbonate, aspartate, and Ammonia. NUCLEOTIDE BIOSYNTHESIS Bio-synthesis of Purines & Pyrimidines e-mail: easybiologyclass@gmail.com mail@easybiologyclass.com www.easybiologyclass.com www.easybiologyclass.com II. In this system, both the salvage precursors [ 3 H]thymidine and [ 14 C]cytidine were incorporated actively into skin DNA and only [ 14 C]cytidine into skin RNA. Uridine monophosphate, or UMP, is used as the example of the pyrimidine nucleotide. Both purines and pyrimidines can be synthesized by 2 alterative pathways: the de novo pathways that metab-olize ribose and amino acids in a series of enzymatic reactions and the salvage pathways that Understand the Two Pathways of nucleotide biosynthesis (1) De-novo synthesis and (2) Salvage Pathways. recycling of the bases. Salvage pathway (recycle pathway): used to recover bases and nucleosides formed during the degradation of RNA and DNA De Novo Synthesis: De novo (all over again) synthesis of purine nucleotides is synthesis of purines anew. 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